Green Infrastructure is the network of green spaces and water systems that delivers multiple environmental, social and economic values and services to urban communities. With the rapid expansion of towns and cities around the world, the value of Green Infrastructure is increasingly recognised by scientific, health, planning and design communities. Green Infrastructure strengthens the resilience of towns and cities to respond to the major current and future challenges of growth, health, climate change and biodiversity loss, as well as water, energy and food security. A review of local and global research and literature reveals that the benefits of Green Infrastructure include modification of temperatures and climatic conditions, improved human health and well-being, enhanced community liveability, more effective water management, increased economic prosperity, greater opportunity for biodiversity conservation and more extensive urban food production. Evidence indicates that without effective Green Infrastructure, towns and cities are at high risk of becoming unhealthy, uncomfortable and unsustainable places. This paper provides an overview of the compelling evidence for incorporation of Green Infrastructure within an integrated approach to urban design and development. Finally this paper outlines the way in which The Green Infrastructure Project in South Australia is working with diverse audiences and stakeholders to develop partnerships, build capacity, raise awareness, create resources and identify opportunities to embrace and integrate Green Infrastructure.